S24G (p.Ser24Gly) variant of IRS1 (Insulin receptor substrate 1)
S24G (p.Ser24Gly) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data.
S24G (p.Ser24Gly) variant details
- p.Ser24Gly
- TOPMed rs1198168717
- gnomAD rs1198168717
- Missense
- Variant Prioritization Score for Impact Estimate 0.5
- REVEL 0.40
- CADD 25.10
- PolyPhen-2 0.87
- SIFT 0.17
- Most common in the East Asian population (allele frequency 2.5e-05)