R89W (p.Arg89Trp) variant of IRS1 (Insulin receptor substrate 1)
R89W (p.Arg89Trp) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data.
R89W (p.Arg89Trp) variant details
- p.Arg89Trp
- gnomAD rs1349427791
- Missense
- Variant Prioritization Score for Impact Estimate 0.614
- REVEL 0.66
- CADD 32.00
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 0.00048)