R33P (p.Arg33Pro) variant of IRS1 (Insulin receptor substrate 1)
R33P (p.Arg33Pro) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data.
R33P (p.Arg33Pro) variant details
- p.Arg33Pro
- TOPMed rs971687069
- gnomAD rs971687069
- Missense
- Variant Prioritization Score for Impact Estimate 0.814
- REVEL 0.81
- CADD 29.90
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00012)