R33G (p.Arg33Gly) variant of IRS1 (Insulin receptor substrate 1)
R33G (p.Arg33Gly) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data.
R33G (p.Arg33Gly) variant details
- p.Arg33Gly
- ExAC rs762833254
- TOPMed rs762833254
- gnomAD rs762833254
- Missense
- Variant Prioritization Score for Impact Estimate 0.696
- REVEL 0.69
- CADD 28.90
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00091)