P65T (p.Pro65Thr) variant of IRS1 (Insulin receptor substrate 1)
P65T (p.Pro65Thr) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data.
P65T (p.Pro65Thr) variant details
- p.Pro65Thr
- 1000Genomes rs149830479
- ESP rs149830479
- ExAC rs149830479
- TOPMed rs149830479
- Missense
- Variant Prioritization Score for Impact Estimate 0.625
- REVEL 0.54
- CADD 22.70
- PolyPhen-2 0.43
- SIFT 0.22
- Most common in the 1KG:MXL population (allele frequency 0.0081)