P5R (p.Pro5Arg) variant of IRS1 (Insulin receptor substrate 1)
P5R (p.Pro5Arg) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data.
P5R (p.Pro5Arg) variant details
- p.Pro5Arg
- gnomAD rs1379631379
- Missense
- Variant Prioritization Score for Impact Estimate 0.325
- REVEL 0.14
- CADD 23.70
- PolyPhen-2 0.25
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 0.00012)