P22S (p.Pro22Ser) variant of IRS1 (Insulin receptor substrate 1)
P22S (p.Pro22Ser) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data.
P22S (p.Pro22Ser) variant details
- p.Pro22Ser
- gnomAD rs1188313973
- Missense
- Variant Prioritization Score for Impact Estimate 0.526
- REVEL 0.34
- CADD 25.30
- PolyPhen-2 0.93
- SIFT 0.32
- Most common in the Non-Finnish European population (allele frequency 8.8e-05)