N115S (p.Asn115Ser) variant of IRS1 (Insulin receptor substrate 1)
N115S (p.Asn115Ser) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data.
N115S (p.Asn115Ser) variant details
- p.Asn115Ser
- ExAC rs754853763
- gnomAD rs754853763
- Missense
- Variant Prioritization Score for Impact Estimate 0.151
- REVEL 0.04
- CADD 18.20
- PolyPhen-2 0.01
- SIFT 0.38
- Most common in the African/African-American population (allele frequency 4.8e-05)