M25V (p.Met25Val) variant of IRS1 (Insulin receptor substrate 1)
M25V (p.Met25Val) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data.
M25V (p.Met25Val) variant details
- p.Met25Val
- TOPMed rs1426755201
- gnomAD rs1426755201
- Missense
- Variant Prioritization Score for Impact Estimate 0.548
- REVEL 0.49
- CADD 24.10
- PolyPhen-2 0.60
- SIFT 0.22
- Most common in the 1KG:CLM population (allele frequency 0.0053)