L66V (p.Leu66Val) variant of IRS1 (Insulin receptor substrate 1)
L66V (p.Leu66Val) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data.
L66V (p.Leu66Val) variant details
- p.Leu66Val
- TOPMed rs1277167453
- gnomAD rs1277167453
- Missense
- Variant Prioritization Score for Impact Estimate 0.67
- REVEL 0.76
- CADD 24.70
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the 1KG:CLM population (allele frequency 0.0053)