L66F (p.Leu66Phe) variant of IRS1 (Insulin receptor substrate 1)
L66F (p.Leu66Phe) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data.
L66F (p.Leu66Phe) variant details
- p.Leu66Phe
- TOPMed rs1277167453
- gnomAD rs1277167453
- Missense
- Variant Prioritization Score for Impact Estimate 0.707
- REVEL 0.82
- CADD 25.30
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 4.8e-05)