K23M (p.Lys23Met) variant of IRS1 (Insulin receptor substrate 1)
K23M (p.Lys23Met) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data.
K23M (p.Lys23Met) variant details
- p.Lys23Met
- gnomAD rs1260297833
- Missense
- Variant Prioritization Score for Impact Estimate 0.711
- REVEL 0.73
- CADD 31.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00091)