H92R (p.His92Arg) variant of IRS1 (Insulin receptor substrate 1)
H92R (p.His92Arg) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data.
H92R (p.His92Arg) variant details
- p.His92Arg
- TOPMed rs1390063552
- gnomAD rs1390063552
- Missense
- Variant Prioritization Score for Impact Estimate 0.574
- REVEL 0.53
- CADD 26.30
- PolyPhen-2 0.78
- SIFT 0.01
- Most common in the 1KG:CLM population (allele frequency 0.0053)