G138S (p.Gly138Ser) variant of IRS1 (Insulin receptor substrate 1)
G138S (p.Gly138Ser) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data.
G138S (p.Gly138Ser) variant details
- p.Gly138Ser
- 1000Genomes rs376142568
- ESP rs376142568
- ExAC rs376142568
- TOPMed rs376142568
- Missense
- Variant Prioritization Score for Impact Estimate 0.306
- REVEL 0.18
- CADD 16.30
- PolyPhen-2 0.01
- SIFT 0.59
- Most common in the East Asian population (allele frequency 0.00015)