G138R (p.Gly138Arg) variant of IRS1 (Insulin receptor substrate 1)
G138R (p.Gly138Arg) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data.
G138R (p.Gly138Arg) variant details
- p.Gly138Arg
- 1000Genomes rs376142568
- ESP rs376142568
- ExAC rs376142568
- TOPMed rs376142568
- Missense
- Variant Prioritization Score for Impact Estimate 0.378
- REVEL 0.26
- CADD 23.70
- PolyPhen-2 0.67
- SIFT 0.01
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)