G133W (p.Gly133Trp) variant of IRS1 (Insulin receptor substrate 1)
G133W (p.Gly133Trp) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data.
G133W (p.Gly133Trp) variant details
- p.Gly133Trp
- ExAC rs758241055
- TOPMed rs758241055
- gnomAD rs758241055
- Missense
- Variant Prioritization Score for Impact Estimate 0.365
- REVEL 0.17
- CADD 23.70
- PolyPhen-2 0.98
- SIFT 0.04
- Most common in the REMAINING population (allele frequency 0.00048)