G128A (p.Gly128Ala) variant of IRS1 (Insulin receptor substrate 1)
G128A (p.Gly128Ala) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data.
G128A (p.Gly128Ala) variant details
- p.Gly128Ala
- TOPMed rs1255364686
- gnomAD rs1255364686
- Missense
- Variant Prioritization Score for Impact Estimate 0.295
- REVEL 0.09
- CADD 14.80
- PolyPhen-2 0.13
- SIFT 0.66
- Most common in the East Asian population (allele frequency 2.5e-05)