E91D (p.Glu91Asp) variant of IRS1 (Insulin receptor substrate 1)
E91D (p.Glu91Asp) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data.
E91D (p.Glu91Asp) variant details
- p.Glu91Asp
- ExAC rs768842504
- TOPMed rs768842504
- gnomAD rs768842504
- Missense
- Variant Prioritization Score for Impact Estimate 0.485
- REVEL 0.52
- CADD 22.50
- PolyPhen-2 1.00
- SIFT 0.06
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)