D90N (p.Asp90Asn) variant of IRS1 (Insulin receptor substrate 1)
D90N (p.Asp90Asn) in IRS1 (Insulin receptor substrate 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data.
D90N (p.Asp90Asn) variant details
- p.Asp90Asn
- ExAC rs772637039
- TOPMed rs772637039
- gnomAD rs772637039
- Missense
- Variant Prioritization Score for Impact Estimate 0.755
- REVEL 0.72
- CADD 28.70
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00012)