W70G (p.Trp70Gly) variant of IRF7 (Interferon regulatory factor 7)
W70G (p.Trp70Gly) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
W70G (p.Trp70Gly) variant details
- p.Trp70Gly
- cosmic curated COSV10635
- ExAC rs747086616
- gnomAD rs747086616
- Missense
- Variant Prioritization Score for Impact Estimate 0.746
- AlphaMissense 0.74
- MetaLR 0.94
- MetaSVM 1.06
- CADD 28.80
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00011)
- Structural context available