R7K (p.Arg7Lys) variant of IRF7 (Interferon regulatory factor 7)
R7K (p.Arg7Lys) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
R7K (p.Arg7Lys) variant details
- p.Arg7Lys
- ExAC rs773962790
- TOPMed rs773962790
- gnomAD rs773962790
- Missense
- Variant Prioritization Score for Impact Estimate 0.587
- AlphaMissense 0.18
- MetaLR 0.85
- MetaSVM 0.42
- CADD 19.10
- PolyPhen-2 0.87
- SIFT 0.42
- Most common in the East Asian population (allele frequency 2.6e-05)
- Structural context available