R69K (p.Arg69Lys) variant of IRF7 (Interferon regulatory factor 7)
R69K (p.Arg69Lys) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
R69K (p.Arg69Lys) variant details
- p.Arg69Lys
- TOPMed rs1023236849
- gnomAD rs1023236849
- Missense
- Variant Prioritization Score for Impact Estimate 0.752
- AlphaMissense 0.53
- MetaLR 0.83
- MetaSVM 0.53
- CADD 23.50
- PolyPhen-2 0.89
- SIFT 0.64
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available