R103H (p.Arg103His) variant of IRF7 (Interferon regulatory factor 7)
R103H (p.Arg103His) in IRF7 (Interferon regulatory factor 7) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
R103H (p.Arg103His) variant details
- p.Arg103His
- rs370737637
- ESP rs370737637
- ExAC rs370737637
- gnomAD rs370737637
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.361
- AlphaMissense 0.14
- MetaLR 0.89
- MetaSVM 0.45
- CADD 9.63
- PolyPhen-2 0.99
- SIFT 0.24
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available