P10L (p.Pro10Leu) variant of IRF7 (Interferon regulatory factor 7)
P10L (p.Pro10Leu) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
P10L (p.Pro10Leu) variant details
- p.Pro10Leu
- ESP rs375150065
- ExAC rs375150065
- TOPMed rs375150065
- gnomAD rs375150065
- Missense
- Variant Prioritization Score for Impact Estimate 0.477
- AlphaMissense 0.31
- MetaLR 0.86
- MetaSVM 0.69
- CADD 23.10
- PolyPhen-2 0.97
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available