L18I (p.Leu18Ile) variant of IRF7 (Interferon regulatory factor 7)
L18I (p.Leu18Ile) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data and structural context.
L18I (p.Leu18Ile) variant details
- p.Leu18Ile
- Ensembl rs2133151784
- Missense
- Variant Prioritization Score for Impact Estimate 0.807
- AlphaMissense 0.62
- MetaLR 0.97
- MetaSVM 1.09
- CADD 24.80
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available