L13R (p.Leu13Arg) variant of IRF7 (Interferon regulatory factor 7)
L13R (p.Leu13Arg) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
L13R (p.Leu13Arg) variant details
- p.Leu13Arg
- 1000Genomes rs532509180
- ExAC rs532509180
- TOPMed rs532509180
- gnomAD rs532509180
- Missense
- Variant Prioritization Score for Impact Estimate 0.329
- AlphaMissense 0.12
- MetaLR 0.66
- MetaSVM -0.23
- CADD 11.30
- PolyPhen-2 0.25
- SIFT 0.94
- Most common in the 1KG:CDX population (allele frequency 0.0057)
- Structural context available