L13P (p.Leu13Pro) variant of IRF7 (Interferon regulatory factor 7)
L13P (p.Leu13Pro) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
L13P (p.Leu13Pro) variant details
- p.Leu13Pro
- 1000Genomes rs532509180
- ExAC rs532509180
- TOPMed rs532509180
- gnomAD rs532509180
- Missense
- Variant Prioritization Score for Impact Estimate 0.444
- AlphaMissense 0.45
- MetaLR 0.93
- MetaSVM 0.78
- CADD 14.30
- PolyPhen-2 1.00
- SIFT 0.13
- Most common in the Latino/Admixed American population (allele frequency 2.4e-05)
- Structural context available