H46Q (p.His46Gln) variant of IRF7 (Interferon regulatory factor 7)
H46Q (p.His46Gln) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
H46Q (p.His46Gln) variant details
- p.His46Gln
- TOPMed rs959601641
- gnomAD rs959601641
- Missense
- Variant Prioritization Score for Impact Estimate 0.599
- AlphaMissense 0.99
- MetaLR 0.97
- MetaSVM 1.09
- CADD 24.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available