G77V (p.Gly77Val) variant of IRF7 (Interferon regulatory factor 7)
G77V (p.Gly77Val) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
G77V (p.Gly77Val) variant details
- p.Gly77Val
- ExAC rs757334669
- TOPMed rs757334669
- gnomAD rs757334669
- Missense
- Variant Prioritization Score for Impact Estimate 0.386
- AlphaMissense 0.13
- MetaLR 0.90
- MetaSVM 0.43
- CADD 14.60
- PolyPhen-2 0.91
- SIFT 0.18
- Most common in the South Asian population (allele frequency 1.3e-05)
- Structural context available