E35D (p.Glu35Asp) variant of IRF7 (Interferon regulatory factor 7)
E35D (p.Glu35Asp) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
E35D (p.Glu35Asp) variant details
- p.Glu35Asp
- TOPMed rs1483910273
- gnomAD rs1483910273
- Missense
- Variant Prioritization Score for Impact Estimate 0.271
- AlphaMissense 0.11
- MetaLR 0.83
- MetaSVM 0.19
- CADD 2.34
- PolyPhen-2 0.00
- SIFT 0.28
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available