A4T (p.Ala4Thr) variant of IRF7 (Interferon regulatory factor 7)
A4T (p.Ala4Thr) in IRF7 (Interferon regulatory factor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
A4T (p.Ala4Thr) variant details
- p.Ala4Thr
- TOPMed rs1397894327
- gnomAD rs1397894327
- Missense
- Variant Prioritization Score for Impact Estimate 0.341
- AlphaMissense 0.16
- MetaLR 0.76
- MetaSVM -0.06
- CADD 7.15
- PolyPhen-2 0.14
- SIFT 0.14
- Most common in the South Asian population (allele frequency 2.6e-05)
- Structural context available