S21L (p.Ser21Leu) variant of IL1RN (P18510)
S21L (p.Ser21Leu) in IL1RN (P18510) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
S21L (p.Ser21Leu) variant details
- p.Ser21Leu
- cosmic curated COSV10726
- Missense
- Variant Prioritization Score for Impact Estimate 0.331
- REVEL 0.14
- CADD 14.70
- PolyPhen-2 0.48
- SIFT 0.13
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available