C25Y (p.Cys25Tyr) variant of IL1RN (P18510)
C25Y (p.Cys25Tyr) in IL1RN (P18510) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
C25Y (p.Cys25Tyr) variant details
- p.Cys25Tyr
- gnomAD rs1406422984
- Missense
- Variant Prioritization Score for Impact Estimate 0.293
- REVEL 0.12
- MetaLR 0.15
- MetaSVM -0.93
- CADD 20.90
- PolyPhen-2 0.46
- SIFT 0.05
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available