H229Y (p.His229Tyr) variant of IDS (Iduronate 2-sulfatase)

H229Y (p.His229Tyr) in IDS (Iduronate 2-sulfatase) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as pathogenic/likely pathogenic in the context of Mucopolysaccharidosis, MPS-II. The record also includes published literature and structural context.

H229Y (p.His229Tyr) variant details