T89R (p.Thr89Arg) variant of HCN4 (Q9Y3Q4)
T89R (p.Thr89Arg) in HCN4 (Q9Y3Q4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
T89R (p.Thr89Arg) variant details
- p.Thr89Arg
- TOPMed rs1459039632
- gnomAD rs1459039632
- Missense
- Variant Prioritization Score for Impact Estimate 0.414
- REVEL 0.28
- MetaLR 0.75
- MetaSVM -0.10
- CADD 20.40
- PolyPhen-2 0.05
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available