I15T (p.Ile15Thr) variant of F9 (Coagulation factor IX)
I15T (p.Ile15Thr) in F9 (Coagulation factor IX) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
I15T (p.Ile15Thr) variant details
- p.Ile15Thr
- gnomAD X-139530808-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.352
- REVEL 0.29
- MetaLR 0.66
- MetaSVM -0.24
- CADD 22.00
- PolyPhen-2 0.01
- SIFT 0.05
- Most common in the Latino/Admixed American population (allele frequency 2.8e-05)
- Structural context available
- Literature evidence available