P114S (p.Pro114Ser) variant of F5 (Coagulation factor V)
P114S (p.Pro114Ser) in F5 (Coagulation factor V) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
P114S (p.Pro114Ser) variant details
- p.Pro114Ser
- cosmic curated COSV10088
- ExAC rs761734890
- TOPMed rs761734890
- gnomAD rs761734890
- Missense
- Variant Prioritization Score for Impact Estimate 0.702
- REVEL 0.78
- CADD 24.30
- PolyPhen-2 0.93
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available