L85F (p.Leu85Phe) variant of F5 (Coagulation factor V)
L85F (p.Leu85Phe) in F5 (Coagulation factor V) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
L85F (p.Leu85Phe) variant details
- p.Leu85Phe
- cosmic curated COSV63127
- gnomAD rs951287890
- Missense
- Variant Prioritization Score for Impact Estimate 0.648
- REVEL 0.71
- CADD 27.20
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available