R91C (p.Arg91Cys) variant of F13A1 (Coagulation factor XIII A chain)
R91C (p.Arg91Cys) in F13A1 (Coagulation factor XIII A chain) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.86 / 1. The record also includes population frequency data and structural context.
R91C (p.Arg91Cys) variant details
- p.Arg91Cys
- ExAC rs775055566
- TOPMed rs775055566
- gnomAD rs775055566
- Missense
- Variant Prioritization Score for Impact Estimate 0.857
- REVEL 0.87
- MetaLR 0.85
- MetaSVM 0.90
- CADD 32.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available