T37M (p.Thr37Met) variant of F11 (Coagulation factor XI)
T37M (p.Thr37Met) in F11 (Coagulation factor XI) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
T37M (p.Thr37Met) variant details
- p.Thr37Met
- rs1377806811
- cosmic curated COSV10510
- TOPMed rs1377806811
- gnomAD rs1377806811
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.463
- REVEL 0.49
- ESM-1b 0.00
- AlphaMissense 0.09
- MetaLR 0.80
- MetaSVM 0.28
- CADD 17.09
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available