R139K (p.Arg139Lys) variant of F11 (Coagulation factor XI)
R139K (p.Arg139Lys) in F11 (Coagulation factor XI) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes structural context.
R139K (p.Arg139Lys) variant details
- p.Arg139Lys
- NCI-TCGA Cosmic COSV9925
- cosmic curated COSV99251
- ExAC rs779556113
- gnomAD rs779556113
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.483
- REVEL 0.52
- ESM-1b 0.00
- AlphaMissense 0.09
- MetaLR 0.76
- MetaSVM 0.42
- CADD 19.64
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available