L86P (p.Leu86Pro) variant of F11 (Coagulation factor XI)
L86P (p.Leu86Pro) in F11 (Coagulation factor XI) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data and structural context.
L86P (p.Leu86Pro) variant details
- p.Leu86Pro
- NCI-TCGA TCGA novel
- Ensembl rs2126726572
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.658
- REVEL 0.80
- ESM-1b 0.00
- AlphaMissense 0.40
- MetaLR 0.77
- MetaSVM 0.68
- CADD 24.40
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available