K121N (p.Lys121Asn) variant of F11 (Coagulation factor XI)
K121N (p.Lys121Asn) in F11 (Coagulation factor XI) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes structural context.
K121N (p.Lys121Asn) variant details
- p.Lys121Asn
- TOPMed rs1358180761
- gnomAD rs1358180761
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.312
- REVEL 0.29
- ESM-1b 0.00
- AlphaMissense 0.38
- MetaLR 0.47
- MetaSVM -0.45
- CADD 11.49
- EBI: Likely benign
- UniProt: Likely benign
- Structural context available