T6S (p.Thr6Ser) variant of EGFR (Epidermal growth factor receptor)
T6S (p.Thr6Ser) in EGFR (Epidermal growth factor receptor) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The record also includes variant effect predictions, experimental measurements, and structural context.
T6S (p.Thr6Ser) variant details
- p.Thr6Ser
- ExAC rs767651648
- TOPMed rs767651648
- gnomAD rs767651648
- Uncertain significance
- Missense
- MetaLR 0.28
- MetaSVM -0.83
- SIFT 0.15
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- Dabrafenib and Cetuximab HT-29 cells, base editing z-scores (predicted consequen: score 0.854