S22T (p.Ser22Thr) variant of EGFR (Epidermal growth factor receptor)
S22T (p.Ser22Thr) in EGFR (Epidermal growth factor receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S22T (p.Ser22Thr) variant details
- p.Ser22Thr
- gnomAD 7-55019342-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.212
- REVEL 0.05
- MetaLR 0.25
- MetaSVM -0.92
- CADD 12.50
- PolyPhen-2 0.00
- SIFT 0.35
- Population evidence available
- Structural context available
- Dabrafenib and Cetuximab HT-29 cells, base editing z-scores (predicted consequen: score -0.0683
- Literature evidence available