P3T (p.Pro3Thr) variant of EGFR (Epidermal growth factor receptor)
P3T (p.Pro3Thr) in EGFR (Epidermal growth factor receptor) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
P3T (p.Pro3Thr) variant details
- p.Pro3Thr
- ExAC rs773069229
- TOPMed rs773069229
- gnomAD rs773069229
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.20
- AlphaMissense 0.07
- MetaLR 0.35
- MetaSVM -0.71
- CADD 10.10
- PolyPhen-2 0.18
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the South Asian population (allele frequency 1.3e-05)
- Structural context available