L15M (p.Leu15Met) variant of EGFR (Epidermal growth factor receptor)
L15M (p.Leu15Met) in EGFR (Epidermal growth factor receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, published literature, and structural context.
L15M (p.Leu15Met) variant details
- p.Leu15Met
- gnomAD 7-55019320-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.465
- REVEL 0.34
- MetaLR 0.62
- MetaSVM -0.15
- CADD 24.20
- PolyPhen-2 0.99
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 9.4e-07)
- Structural context available
- Literature evidence available