K28E (p.Lys28Glu) variant of EGFR (Epidermal growth factor receptor)
K28E (p.Lys28Glu) in EGFR (Epidermal growth factor receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
K28E (p.Lys28Glu) variant details
- p.Lys28Glu
- ExAC rs749088691
- gnomAD rs749088691
- Missense
- Variant Prioritization Score for Impact Estimate 0.389
- REVEL 0.27
- MetaLR 0.38
- MetaSVM -0.58
- CADD 23.40
- PolyPhen-2 0.00
- SIFT 0.46
- Most common in the Finnish in Finland (FIN) population (allele frequency 2.1e-05)
- Structural context available