E26K (p.Glu26Lys) variant of EGFR (Epidermal growth factor receptor)
E26K (p.Glu26Lys) in EGFR (Epidermal growth factor receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, published literature, and structural context.
E26K (p.Glu26Lys) variant details
- p.Glu26Lys
- gnomAD 7-55019353-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.406
- REVEL 0.34
- MetaLR 0.27
- MetaSVM -0.75
- CADD 22.90
- PolyPhen-2 0.02
- SIFT 0.82
- Most common in the Non-Finnish European population (allele frequency 9.5e-07)
- Structural context available
- Literature evidence available