C19C (p.Cys19Cys) variant of EGFR (Epidermal growth factor receptor)

Name: EGFR C19C (p.Cys19Cys) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-07-23
License: https://catvariant.com/terms-of-use

C19C (p.Cys19Cys) in EGFR (Epidermal growth factor receptor) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.

C19C (p.Cys19Cys) variant details

p.Cys19Cys
rs866936692
gnomAD 7-55019334-C-T
Synonymous
Variant Prioritization Score for Impact Estimate 0.136
CADD 7.84
Most common in the Non-Finnish European population (allele frequency 9.4e-07)
Structural context available
Dabrafenib and Cetuximab HT-29 cells, base editing z-scores (predicted consequen: score 0.838
Literature evidence available